Karou is not your typical teenager. Having blue hair, living in her own apartment, speaking many languages, and being an art student in Prague set her apart from many other 17-year-olds… but there’s much more to it than that. She also travels around the world to collect teeth for a chimaerae named Brimstone who is, basically, her foster father. She has no idea why he needs those teeth, but she is sure that his dwindling supply is a problem. People credit Karou’s imagination with creating all of the fantastic creatures in her sketchbooks, and she is more than happy to let them believe what they want, but the creatures are very real to her. In fact, these chimaerae are the only family she has ever known. When angels mysterious appear all around Earth, using their scorched handprints to seal off the doors that act as portals between Earth and the land in which those monsters exist, Karou ends up locked out. She has always been taught that the chimaerae were good and that the angels were actually horrible monsters, and now she has to fend off these killer angels without any help from Brimstone. Karou can’t help being attracted to one of the angels, though, and wonders if there’s a reason why she has a strange feeling that she’s somehow connected to him already…